Combined elemental Mg ~424 mg/day. NIH tolerable upper limit from supplements is 350 mg/day. Split AM/PM reduces GI load. Loose stools are the practical signal — reduce dose if not
Finasteride blocks testosterone → DHT conversion. Optimizing total T while on finasteride raises serum T but suppresses DHT pathway. Any testosterone-support supplements will behav
Tirzepatide + ALL oral supplementsMinorHigh
Tirzepatide slows gastric emptying. Take all oral supplements 1-2h before injection or space consistently on injection day. Not a safety concern at current doses — timing/absorptio
Tirzepatide + Dihydroberberine (DHB in GLP-1 Supreme)ModerateModerate
Both tirzepatide and DHB lower blood glucose via complementary mechanisms (GLP-1/GIP vs AMPK). Additive effect possible — monitor for hypoglycemia symptoms (shakiness, sweating, co
Curcumin (GLP-1 Supreme) + MontelukastMinorLow
Curcumin inhibits CYP3A4 mildly. GLP-1 Supreme provides ~54 mg active curcumin — likely below clinically significant threshold. Awareness flag only at current dose.
Regular H2 blocker use reduces stomach acid and can impair Mg and B12 absorption. As-needed (PRN) use at current frequency is low risk. B-Complex provides B12 coverage. Monitor if
Finasteride + CreatineMinorLow
Single small RCT found creatine raised DHT ~56%; finasteride blocks DHT conversion. Net effect on serum DHT unclear. Not actionable at this confidence level — informational only.
OPCs in grape seed extract have mild CYP3A4 inhibitory activity, additive with curcumin. Combined effect at current doses almost certainly trivial. Awareness flag.
Dual Magnesium Stack — GI noteMinorHigh
NIH UL for supplemental Mg = 350 mg/day. Current stack = ~424 mg elemental/day (Malate AM + Glycinate PM). Above UL. Split timing (AM + PM) reduces single-dose GI load. Loose stool
Both provide glycine: Neuro-NAC has 525 mg glycine per serving; collagen provides ~4-5 g glycine per 20 g serving. Not a safety concern — beneficial overlap. Total glycine intake i
TMG + CreatinePositiveHigh
Creatine synthesis (via guanidinoacetate methylation) is a major methyl-group consumer. TMG offsets the drain via BHMT pathway, supporting both creatine biosynthesis and overall me
Folate/methylcobalamin pathway + BHMT/TMG pathway both feed methionine regeneration. Combined approach lowers homocysteine more effectively than either alone.
Brain Health (220 mg Ca/serving) + Magnesium Malate (AM)MinorModerate
Ca and Mg compete at DMT1 transporter and metallothionein. Brain Health placed at LUNCH (separated from AM Mg Malate) to avoid competition.
UC-II + Collagen Peptides + foodMinorModerate
UC-II works via oral immune tolerance (Peyer's patches), not as building block. Best on empty stomach for absorption of intact epitopes. Take at bedtime, >2 hrs after dinner and aw
Biotin at supplement doses interferes with streptavidin-biotin based lab assays (TSH, troponin, PTH, vit D, ferritin, beta-hCG). Stop Thorne B-Complex 48-72 hours before any blood
TMG is a methyl donor; glycine acts as methyl acceptor (via GNMT). Adequate glycine from collagen (4-5 g/serving) and Neuro-NAC (525 mg) helps TMG's methyl groups land correctly. N